Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg
625%
Vitamin K activity from:Vitamin K1 (as phytonadione)Vitamin K2 (as menaquinone-4)Vitamin K2 (as trans menaquinone-7)
2,100 mcg1,000 mcg1,000 mcg100 mcg
1,750%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
Read More
8
Vitamin D3 improves cholesterol levels
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 treatment influences cholesterol levels in patients with ischemic heart disease (IHD) who were also vitamin D deficient. In total, 44 patients participated, and we divided them into two groups: one received vitamin D3 supplements, while the other was given a placebo.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
Read More
9
Vitamin D3 reduces triglycerides and cholesterol
We evaluated how vitamin D3 supplementation influences cholesterol levels in overweight or obese women through a comprehensive meta-analysis of randomized controlled trials. Our focus was on understanding whether this vitamin could effectively improve lipid profiles, specifically high cholesterol levels.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
Read More
Most Useful Reviews
7.5
Life quality boost
91 people found this helpful
I've taken this vitamin for three months, and I can genuinely see the difference. My quality of life has greatly improved; no more fatigue, better motivation to rise out of bed, increased energy, sharper concentration, and a significant lift in my mood. I highly recommend it.
Read More
9
Immunity boost
3 people found this helpful
I adore Life Extension, as their quality is exceptional. I was prescribed this vitamin D with iodine and K to elevate my vitamin levels. After a month, my health markedly improved, and lab tests proved this. I feel more vigorous and stronger. I definitely recommend it! The capsules are small, easy to swallow—a single capsule suffices. My immunity is stronger thanks to this product too.
Read More
9
Cycle regulation
1 people found this helpful
This product is very high quality. After using it for two months, my menstrual cycle normalised, hair loss decreased, and fatigue dissipated. After four months, I had tests for TSH hormones and a thyroid ultrasound; everything was normal. My endocrinologist confirmed that these vitamins are safe to use. Overall, I am very pleased.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
- All Researches
9
Vitamin D3 reduces triglycerides and cholesterol
We evaluated how vitamin D3 supplementation influences cholesterol levels in overweight or obese women through a comprehensive meta-analysis of randomized controlled trials. Our focus was on understanding whether this vitamin could effectively improve lipid profiles, specifically high cholesterol levels.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
Read More
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
Read More
9
We explored the impact of vitamin D3 on cholesterol levels, specifically in individuals taking olanzapine, an antipsychotic medication known to cause dyslipidemia, a condition characterized by abnormal lipid levels. By analyzing various sources including the FDA Adverse Event Reporting System and electronic medical records, we aimed to uncover whether vitamin D3 supplementation could alleviate the cholesterol imbalances caused by olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Read More
8
Vitamin D3 improves cholesterol levels
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 treatment influences cholesterol levels in patients with ischemic heart disease (IHD) who were also vitamin D deficient. In total, 44 patients participated, and we divided them into two groups: one received vitamin D3 supplements, while the other was given a placebo.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
Read More
8
Vitamin D3 and cholesterol reduction
We investigated whether vitamin D3 could help lower cholesterol and alleviate effects from Helicobacter pylori (Hp) infection in mice with high cholesterol. Through an 8-week oral treatment, we found that vitamin D3 showed promise in enhancing liver function by increasing the activity of vitamin D receptors (VDR) in liver tissues.
Notably, there was a marked decrease in serum cholesterol levels after the treatment. We also observed a reduction in the expression of certain inflammatory markers in the gastric tissues, indicating a potential link between vitamin D3 and inflammation reduction associated with Hp infection.
Furthermore, our findings suggested that vitamin D3 may help manage gastritis symptoms by blocking a specific signaling pathway known as JAK/STAT3. However, while the study demonstrated some beneficial effects, it’s important to note that these results were obtained in a controlled environment and might not directly translate to humans without further research.
Notably, there was a marked decrease in serum cholesterol levels after the treatment. We also observed a reduction in the expression of certain inflammatory markers in the gastric tissues, indicating a potential link between vitamin D3 and inflammation reduction associated with Hp infection.
Furthermore, our findings suggested that vitamin D3 may help manage gastritis symptoms by blocking a specific signaling pathway known as JAK/STAT3. However, while the study demonstrated some beneficial effects, it’s important to note that these results were obtained in a controlled environment and might not directly translate to humans without further research.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Life quality boost
91 people found this helpful
I've taken this vitamin for three months, and I can genuinely see the difference. My quality of life has greatly improved; no more fatigue, better motivation to rise out of bed, increased energy, sharper concentration, and a significant lift in my mood. I highly recommend it.
Read More
9
Immunity boost
3 people found this helpful
I adore Life Extension, as their quality is exceptional. I was prescribed this vitamin D with iodine and K to elevate my vitamin levels. After a month, my health markedly improved, and lab tests proved this. I feel more vigorous and stronger. I definitely recommend it! The capsules are small, easy to swallow—a single capsule suffices. My immunity is stronger thanks to this product too.
Read More
9
Cycle regulation
1 people found this helpful
This product is very high quality. After using it for two months, my menstrual cycle normalised, hair loss decreased, and fatigue dissipated. After four months, I had tests for TSH hormones and a thyroid ultrasound; everything was normal. My endocrinologist confirmed that these vitamins are safe to use. Overall, I am very pleased.
Read More
9
Fatigue relief
6 people found this helpful
I was suffering from tiredness and fatigue due to low vitamin D levels. After taking this supplement, those symptoms vanished. I plan to continue using it in the future, although the price is a bit steep. Please consider reducing it.
Read More
0
Iodine high concerns
2 people found this helpful
I was enticed by the high vitamin D with K content; however, I should have checked the iodine amount. I have Hashimoto's disorder, and the iodine content is excessively high. I must dispose of all four unopened bottles since I wouldn't dare give it away, even without a thyroid condition. All the literature I’ve read on Hashimoto advises against iodine supplements.
Read More
Frequently Asked Questions
7.5
Caution advised
20 people found this helpful
Excellent quality, yet caution is necessary for daily use. This supplement contains a high level of iodine. After using it daily for two months, I noticed an increase in thyroid gland activity and occasional facial redness from excessive iodine. Despite this, I find it beneficial in managing my underactive gland.
9
Immunity boost
3 people found this helpful
I adore Life Extension, as their quality is exceptional. I was prescribed this vitamin D with iodine and K to elevate my vitamin levels. After a month, my health markedly improved, and lab tests proved this. I feel more vigorous and stronger. I definitely recommend it! The capsules are small, easy to swallow—a single capsule suffices. My immunity is stronger thanks to this product too.
7.5
Enhanced energy levels
An excellent preparation! In December 2016, my vitamin D level was alarmingly low at 6 ng/ml. Despite initial reluctance from my doctor, I began taking 600 units of vitamin D irregularly, yielding no results. However, after consulting an anti-aging specialist and selecting this combination of vitamins D and K, I took 10,000 units daily with Omega-3 for two weeks. My vitamin D absorption improved to 40 ng/ml in a month, resulting in better mood, increased motivation for physical activities, and easier mornings. I recommend ongoing monitoring and consultation with a specialist for effective dosage management.
7.5
Life quality boost
91 people found this helpful
I've taken this vitamin for three months, and I can genuinely see the difference. My quality of life has greatly improved; no more fatigue, better motivation to rise out of bed, increased energy, sharper concentration, and a significant lift in my mood. I highly recommend it.
9
Cycle regulation
1 people found this helpful
This product is very high quality. After using it for two months, my menstrual cycle normalised, hair loss decreased, and fatigue dissipated. After four months, I had tests for TSH hormones and a thyroid ultrasound; everything was normal. My endocrinologist confirmed that these vitamins are safe to use. Overall, I am very pleased.
7.5
Improved mood
1 people found this helpful
Effectively. Available. My wife had issues with her thyroid gland (hypothyroidism) and vitamin D deficiency, prompting us to find a suitable medication. We chose this drug for its good dosage of vitamins D and K, as well as iodine. It proves to be cost-effective and convenient since it combines several supplements into one tablet. Following its use, I experienced an uplifted mood, felt more energetic, and found it easier to rise in the mornings. However, it is advisable to take it under medical supervision and ensure that necessary tests are conducted to determine deficiencies.
2
Hair loss observed
2 people found this helpful
I have purchased this vitamin D multiple times. Each time I noticed that my hair significantly thinned out as soon as I began taking it, a concern echoed by my mother and son. While vitamin D levels increase, the high dosage of iodine may lead to hair loss. However, results can vary between individuals.
9
Vitamin D rise
1 people found this helpful
I recently learned that high doses of vitamin D should be taken with vitamin K for optimal absorption. After I began taking this, my vitamin D levels quickly increased, as confirmed by tests. Prior to this, my levels wouldn’t rise despite my efforts.
6
Supports high cholesterol
1 people found this helpful
This component of vitamin D and K is essential as vitamin D aids in transporting calcium from the intestines to the blood, while vitamin K guides calcium into the bones. It's particularly beneficial for those with high cholesterol since cholesterol essentially consists of fat accompanied by calcium.
7.5
Effective supplement
2 people found this helpful
This multivitamin is quite high in content; if your multivitamin contains more than 50mg of vitamin D, I recommend taking it every other day. If you lack vitamin D in your diet, a daily dose is fine. It seems effective, as my bone density test yielded normal results.
9
Vitamin D3 reduces triglycerides and cholesterol
We evaluated how vitamin D3 supplementation influences cholesterol levels in overweight or obese women through a comprehensive meta-analysis of randomized controlled trials. Our focus was on understanding whether this vitamin could effectively improve lipid profiles, specifically high cholesterol levels.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
In analyzing 13 studies, we found that vitamin D3 supplementation significantly reduced triglyceride (TG) and total cholesterol (TC) levels while also increasing high-density lipoprotein cholesterol (HDL-C), which is considered “good” cholesterol. Specifically, TG levels decreased by an average of about 6.13 mg/dL and total cholesterol levels decreased by approximately 4.45 mg/dL. Additionally, we saw a noteworthy boost in HDL-C levels, which increased by 1.54 mg/dL.
It's fascinating to note that the most notable reductions in triglycerides occurred in participants who started with higher baseline levels and those who were administered vitamin D3 for 26 weeks or less. However, we should be transparent that vitamin D3 did not show a significant effect on low-density lipoprotein cholesterol (LDL-C) concentrations, which is often a key concern in cholesterol management. Overall, our findings suggest that while vitamin D3 has a positive impact on certain aspects of lipid profiles, it may not be a comprehensive solution for all cholesterol issues.
9
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
8
Vitamin D3 improves cholesterol levels
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 treatment influences cholesterol levels in patients with ischemic heart disease (IHD) who were also vitamin D deficient. In total, 44 patients participated, and we divided them into two groups: one received vitamin D3 supplements, while the other was given a placebo.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
After a five-week treatment period, we observed some interesting results. In the group that received vitamin D3, levels of high-density lipoprotein (often referred to as “good cholesterol”) significantly increased, while triglycerides—a type of fat in the blood—decreased notably. These changes are beneficial as higher HDL levels and lower triglycerides can improve heart health.
These findings highlight the potential for vitamin D3 to play a positive role in managing cholesterol levels among IHD patients. While we noted these improvements in lipid profiles, the correlation between vitamin D levels and C-reactive protein, a marker of inflammation in the body, was not significant in our study, indicating that while vitamin D shows promise, more research is warranted.
References
- Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. 10.1093/nutrit/nuae226
- Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. 10.1615/CritRevImmunol.2024052129
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Xu W, Wang L, Yang L, Li X, Li C, et al. [Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024;40:520.
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. 10.3390/nu16091331
- Oczkowicz M, Szymczyk B, Świątkiewicz M, Wierzbicka A, Steg A, et al. Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats. Mol Biol Rep. 2024;51:456. 10.1007/s11033-024-09408-6
- Yang HE, Lee BW, Choi IJ, Oh JY, An EJ. Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study. J Spinal Cord Med. 2025;48:93. 10.1080/10790268.2023.2257850
- Habiba E, Ali S, Ghanem Y, Sharaki O, Hewedy W. Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients. Can J Physiol Pharmacol. 2023;101:610. 10.1139/cjpp-2022-0359
- Sandgruber F, Höger AL, Kunze J, Schenz B, Griehl C, et al. Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study. Nutrients. 2023;15. 10.3390/nu15071645
- Zhou Z, Nagashima T, Toda C, Kobayashi M, Suzuki T, et al. Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Front Pharmacol. 2023;14:1135516. 10.3389/fphar.2023.1135516
- Hariri Z, Kord-Varkaneh H, Alyahya N, Prabahar K, Găman MA, et al. Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey. Life (Basel). 2023;13. 10.3390/life13020581
